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most comprehensive evaluation to date of the worldwide influence of depression was carried out in 1990 as part of the Global Burden of Disease (GBD) study.

The increased injury to frontal and subcortical brain circuitry following stroke, transient ischemia, and hypertension may explain the excessive prevalence of depression in older individuals with vascular threat components. 63 , sixty five A recent research has advised that cerebrovascular disease might have an etiopathological role in late-life melancholy. Conversely, excessive charges of depression have been present in older patients affected by cerebrovascular illness.

 

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