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mechanism of such toxicity is the loss of oxygen due to competitive binding of CO to the hemoglobin heme groups. Cardiovascular changes also may be observed by CO exposures that create COHb in excess of 5%. In the early 1990s, Health Effects Institute performed a series of studies associated with cardiovascular disease to determine the potential for angina pectoris with COHb levels in the range of 2–6%. The results showed that premature angina can occur under these situations but that the potential for the occurrence of ventricular arrhythmias

 

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