cannabinoid receptor 1 (CB1), which in turn influences intestine permeability through ZO-1 and occludin.a hundred Treatment with the prebiotic OFS also resulted in lowered intestine permeability in obese mice.100 Different studies have shown that a blockade of the CB1 receptor leads to reduction of obesity, although the mechanism is unclear.a hundred and one,102 Moreover, the SCFAs acetate, butyrate, and propionate could strengthen the intestinal epithelial barrier, as they’ve been proven to have positive effects on mucin production103 and
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