launched by units and the resulting surface changes of the degrading biomaterials activate the immune system . The interaction between the host immune system and the biomaterial depends on the tissue surrounding the implant, which can drive the tissue-specific innate defenses and the next induction of adaptive immune responses. In reality, it is becoming extra apparent that macrophages resident in tissues or recruited from other websites play distinct roles in the therapeutic process likewise implantation of the same materials into totally different sites elicits
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