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introductory article sets the scene for this special problem on water, infrastructure and political rule. It makes the case for revisiting the complicated relationships between these three dimensions which have fascinated scholars since Wittfogel’s pioneering – if a lot criticised – work on causal hyperlinks between massive-scale irrigation techniques and autocratic leadership. Scholarship on water, on infrastructure, as well as on political rule has made huge advances since Wittfogel’s days, requiring a wholesome reappraisal of their triangular relationship. In this article, we evaluation the related advances in scientific information and epistemological approaches on each dimension. We subsequently summarise the alternative ways by which every of the next papers takes up and interrogates the relationship between water, infrastructure and political rule prior to the final paper which synthesises the principal findings emerging from the particular issue. This chapter can’t comply with the detailed format for the economic evaluation of different preventive interventions devised for the illness-specific chapters, because the exposures, health results, and interventions are too varied and due to the lack of overarching examples of financial assessments. Nevertheless, it does current a few examples of the types of analyses out there. Acute publicity to contaminants in ingesting water can cause irritation or inflammation of the eyes and nostril, pores and skin, and gastrointestinal system; nonetheless, crucial health effects are because of chronic exposure to copper, arsenic, or chromium in ingesting water. Excretion of chemical substances by way of the kidney targets the kidney for toxic results, as seen with chemical substances such as cadmium, copper, mercury, and chlorobenzene . Estimating precise exposure through water involves analyzing

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